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The benefit of fenoldopam in terms of AKI occurrence is difficult to evaluate due to heterogenous delays in administration and diagnosis criteria among studies.
But estimating rates of an event with very low probability of occurrence is difficult without more data than we have.
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The calendar dating of historical events and the determination of how many days have elapsed since some astronomical or other occurrence are difficult for a number of reasons.
In real world, both the probability and the consequence of an event occurrence are difficult to quantify.
Trends in symptom occurrence were difficult to identify.
Hence, the impact of GCSF on FN occurrence was difficult to assess.
Yet tracking an uptick in occurrences is difficult because no one has been sampling blooms globally for long enough, he said.
Comprehensive surveillance of all adverse occurrences is difficult, if not impossible.
"Such occurrences are difficult to digest.
These occurrences are difficult to model, since the probability of such a high-coverage bin arising by pure chance is very low.
However, because previous studies evaluated the use of NSAIDs after the initial fracture occurrence, it is difficult to determine whether NSAID use in those studies was a result of pain associated with an undiagnosed healing complication or whether it was a risk factor for the healing complication (Giannoudis et al. 2000, Bhandari et al. 2003, Bhattacharyya et al. 2005).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com