Calpastatin binds to both P and P′ sides of the active site, but does not occupy the active site, thus avoiding self-immolation.
An additional contrast between the uncleaved and cleaved structures is that in the former, water molecules occupy the active site, whereas in the latter the Fo – Fc omit map showed large positive density in the active site into which a molecule of Asp was modeled.
Molecular docking also revealed the propensity of morin to occupy the active site of PHLPP2 enzyme.
This unexpected reactivity allowed us to bridge in situ two adenosine derivatives to fully occupy the active NAD site.
TPD profiles of Ag/Al2O3 showed that nitrates formed over the catalyst were quite stable at low temperatures, which might occupy the active sites and were unfavorable to SCR reactions.
Therefore, it can be concluded that the presence of the submonolayer of Pt in this bimetallic system has helped hydroxyl species occupy the active sites, and consequently, it is not an appropriate catalyst for oxygen reduction reaction.
Molecular modeling and kinetic studies revealed that compound 6e was a competitive MAO-B inhibitor, which can occupy the active site of MAO-B, and interact with Aβ (1 42) via π-π and cation π stacking interactions.
However, the intermediates, which are produced in the process of PCO, shouldn't be ignored because they can occupy the active sites of catalyst and lead to the deactivation of the catalyst.
A specific polymer was determined to be most effective due to its unique capability to occupy the active stacking sites of asphaltene aggregates (i.e. aromatic cores), thereby preventing further π π stacking of asphaltenes.
Depending on the child's age and temperament, that might mean two stories, a 10-minute cuddle and a lava lamp to occupy an active mind while the child drifts off to sleep.
