Most plausibly, having occupied a suitable niche, a cell now able to express its self-renewal programme and producing daughter cells which differentiate to populate the bulk malignancy, becomes a CSC.
We performed separate GIS analyses to map occupied, suitable, potentially suitable, and unsuitable habitat types within the PPA and to determine how conservation actions might impact the oil and gas activities (See definitions in Methods, below; Figure 7).
Historical and biological barriers may prevent a species from occupying all suitable habitat [13], [37].
If an expanding cell cannot find a suitable vacant hexagon, the cell attempts to occupy an already occupied adjacent hexagon nearest to its core position.
Neither species occupied all suitable localities, indicating dispersal limitation.
The servo loop occupies a small area and is suitable for built-in self-test application.
In contrast, P. t. ellioti occupies a much broader range of suitable habitat, including moist rainforest, woodlands, and open savanna, with more than 80% of the ENM for P. t. ellioti defined by trends in slope, temperature seasonality, tree cover, and precipitation.
Sixty-two percent of the primary population area (PPA) contained occupied, suitable, or potentially suitable habitat, leaving 38% that could be considered for oil and gas development.
As a result, the PPA analysis performed for conservation planning identified 263,196 ha (62% of the much smaller PPA) as occupied, suitable, or potentially suitable habitats where oil and gas development should be excluded.
We selected a method only requiring presence data since these methods have been shown to outperform regression methods where a species does not occupy all available suitable habitats [7].
