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The phrase "occupy a large portion" is grammatically correct and can be used in written English.
It means to take up a significant amount of space, time, or resources. Example: "The new shopping mall will occupy a large portion of the prime real estate downtown." In this sentence, "occupy a large portion" is used to describe the amount of space the shopping mall will take up.
Exact(15)
The nomination of even a single Supreme Court candidate and the ensuing confirmation debate would by itself be a momentous event that would occupy a large portion of the administration's political attention and energy.
Such private arrangements occupy a large portion of Abercrombie's business, but well-off travelers who want to design the trip experience are also turning to boutique-type services like the NextGreatPlace and Quintess Beyond for locations, hotels and service that have been screened and approved in advance.
However, polymeric carriers can occupy a large portion of the vessel volume, thus compromising load capacity.
Rangelands occupy a large portion of the Earth's land surface and provide many ecosystem services to human populations around the world.
The study shows that native-born neighbourhoods occupy a large portion of Abu Dhabi's landscape, with 55.2% of the total land designated for development.
Since biocrusts occupy the same niche, we might expect that annual grass invasion could be inhibited when biocrusts occupy a large portion of the soil surface.
Similar(44)
When you can't make ends meet, the weight of worry occupies a large portion of the mind.
The frontal gland of some termites (e.g., Coptotermes and Rhinotermes) occupies a large portion of the abdominal cavity and opens by means of a frontal pore (fontanelle), through which the liquid is ejected.
"One story is that it was because of the Turks," Mr. Visztenvelt said, referring to the era when the Ottoman Empire occupied a large portion of what is today Hungary.
The flight from Sao Paulo – on a modern passenger jet, for the record – pauses briefly in the seafront city of Recife before continuing out into the Atlantic, and touching down on an airstrip that occupies a large portion of the lush, green interior.
This difference occupies a large portion of the similarity calculation; hence, all the calculation results are similar.
More suggestions(14)
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become a large portion
occupy a vast portion
occupy a substantial portion
occupy a massive portion
fill a large portion
seize a large portion
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employ a large portion
fills a large portion
engaged a large portion
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occupied a large portion
constitute a large portion
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com