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This study was designed to quantify possible bias in occupationally relevant postures, and test whether INC performance could be improved using calibration.
Participants in two treatment conditions showed greater gains than control condition participants in career decidedness as measured by the Occupational Alternatives Questionnaire (d = .54), occupationally relevant self-knowledge (d = .58), and emission of career exploration behaviors (d = .50).50
Occupationally relevant in vivo exposures (10 to 80 μg/mouse) and pulmonary fibroblast in vitro exposure studies, using in vivo dose equivalents (0.02 to 0.2 μg/cm2), resulted in dose-dependent transient pulmonary inflammation followed by fibroblast cell proliferation, alveolar wall thickening, and collagen I production culminating in persistent pulmonary fibrosis [9,10].
Based on the increased resistance of WI38 cells to Cr VI), we examined their telomere damage with higher but still occupationally relevant Cr VI) concentrations.
Although Cr VI) at higher concentrations can induce ROS, the mutagenic and genotoxic effects at occupationally relevant levels are ascribed to various Cr-DNA and Cr-protein-DNA adducts that impede replication fork progression particularly at G-runs as in telomere repeats [11], [24], [25], [28].
Studies show that MWCNTs can persist in the lung for long periods and cause toxic responses even after short, occupationally relevant exposures.
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The goal of this study was to gain insight into the disease process by which an occupationally and possibly environmentally relevant human carcinogen induces chronic lung damage.
One of the major strengths of the present study is that by using a whole-body inhalation system and an occupationally realistic exposure concentration, the exposure conditions were relevant to human exposure scenarios.
The study sample was restricted to men because we expected few women to be occupationally exposed to diesel and gasoline emissions during the relevant exposure periods (between the 1960s 1990s).
These results will be of particular relevance to professionals who are occupationally exposed to macaques.
The goals of this study were to identify potential biomarkers of benzene exposure and/or early effects and to elucidate mechanisms relevant to risk of hematotoxicity, leukemia, and lymphoid malignancy in occupationally exposed individuals, many of whom were exposed to benzene levels < 1 ppm, the current U.S. occupational standard.
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