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Plausible examples are: repeated studies of the effect of pollutants in a community, recurring studies of occupational mortality, or an ongoing study of a particular risk factor found in individual life insurance underwriting.
Background: Perfluorooctanoic acid (PFOA) has been linked to cancer in occupational mortality studies and animal toxicologic research.
Lead and lead compounds are reasonably anticipated to be human carcinogens based on evidence from occupational mortality and animal studies [ National Toxicology Program (NTP) 2005].
Earlier studies of human health effects of PFOA in relation to adult chronic diseases have been reviewed previously (C8 Science Panel 2012; Steenland et al. 2010) and include occupational mortality and medical surveillance studies and a few community studies.
In an occupational mortality analysis of 486,000 adult male death records filed in Washington State in the years 1950-1982, leukemiandnd the non-Hodgkin's lymphomas show increased proportionate mortality ratios (PMRs) in workers employed in occupations with intuitive exposures to electromagnetic fields.
Several authors have suggested that potential confounders in occupational mortality studies are unlikely to be sufficiently highly correlated with both the exposure and the outcome to completely explain a positive association of the magnitude seen here (Blair et al. 2007; Kriebel et al. 2004; Siemiatycki et al. 1988).
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The present study has the typical limitations of occupational cohort mortality studies.
IARC sponsored an occupational cohort mortality study of 21,863 workers across 12 countries exposed to phenoxy herbicides.
Other findings from the occupational cohort mortality studies have been inconsistent, with excesses in one but not the other.
To our knowledge, this is the first occupational cohort mortality study to report an association between PCB exposure and myeloma.
We present the data for three functions that in combination provide useful guidelines for occupational cancer mortality risk.
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