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These include occupancy studies and mechanism of action studies.
There are two areas where PET is particularly useful in this respect, namely biodistribution and drug occupancy studies.
Genome-wide occupancy studies have shown AP2-O to bind the promoters of most genes deregulated in the knockout parasite28 and that AP2-G2 tabouts about 1500 genes mostly required for asexual replication, repressing them before commitment to sexual differentiation29.
This derivative illustrates proof-of-concept for the preparation of other useful fluorophoric antimuscarinic agents which have potential utility in receptor occupancy studies and high throughput screens.
So-called receptor occupancy studies measure just that.
The results support the use of PET and 11C-TMSX as a suitable tool for receptor occupancy studies.
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Building on design recommendations from the previous chapter, we highlight additional issues that must be considered when designing a multiple-season occupancy study.
To determine factors influencing their distribution, we conducted a multi-scale occupancy study throughout the range of the Sherman's fox squirrel (S. n. shermani) in Florida.
11 C]GSK931145 demonstrated good brain penetration and usefulness for GlyT1 occupancy study in monkeys [21].
Data from a dopamine D3/D2 receptor occupancy study with [11C]--PHNO were used.
Fig. 2 Summary of displacements introduced by FBF and GIR MC methods for [11C]--PHNO PET occupancy study data.
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