Sentence examples for occupancy effect from inspiring English sources

Brody AL, Mandelkern MA, Costello MR, Abrams AL, Scheibal D, Farahi J, et al. Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette.

The objective of this study was to examine whether this sensitivity is due to a central pharmacokinetic (i.e., higher occupancy for a given plasma level) or pharmacodynamic (i.e., greater functional effects for a given occupancy) effect.

Second, the open loop circuit shows the single scaffold occupancy effect at lower concentrations of scaffold.

In simulation data, we see that the scaffold occupancy effect is mitigated by higher levels of response regulator.

Experimental data for tuning response regulator concentration via 10-fold increases of arabinose do not extend the scaffold levels far enough to show the occupancy effect, but the increasing output gain is evident.

Though it is not intuitive, this can be explained as the scaffold single occupancy effect, where an overabundance of free scaffold leads to binding of only kinase or response regulator but not both.

The mass of injected ligand in each second scan was carefully adjusted to that in each first scan because of potential occupancy effects by unlabelled ligand itself [33], [34], and no significant difference was found in the mass of injected ligand as well as the injected dose and specific activity between the first and second scans in each group, using paired Student t test.

Using a conservative criterion for classification, discarding probes overlapping ncRNA genes and only considering neighboring probes, still results in the co-occupancy effect among the neighboring probes, suggesting that neither the high copy number of tRNAs nor of their associated Ty elements are responsible for the co-occupancy effect.

Their right of occupancy was, in effect, abandoned; and, full consideration for it being afterwards paid, it could not be resumed.

Compared to pharmacokinetic properties, pharmacodynamic properties are more difficult to scale [ 156], since they are not often related to bodyweight (e.g. receptor occupancy, transduction, maximal effect, etc).

After adjustment for occupancy structure, the effect of day type on mortality was reduced but still noticeable (mortality rate ratio 1.14, 1.02 to 1.28; P=0.025).