Minimum duration-based methods need to store the occupancy durations of each channel so that the least used can be identified.
The present results, together with our previous work (Bailey et al., 2004; Johnson et al., 2006), reveal that there are four main factors that determine the development of MOPr desensitization: the nature of the agonist ligand; the degree of receptor occupancy; the duration of morphine treatment; and the level of PKC activation.
These studies found that endotoxin was higher in old buildings, with longer duration of occupancy, low ventilation rate, and poor housekeeping.
The question becomes whether the duration of the occupancy by the "house-sitter" constitutes an "illegal sublet" rather than the stay of a guest or roommate.
Because Akhenaton chose a new, unused site for his capital and because of the relatively short duration of its occupancy, the excavators could reconstruct an unusually accurate picture of the layout of the city.
It is possible to estimate the duration of glacial occupancy of valleys in the Two Thumb Range, and the pattern is one of very limited glaciation of the southern valleys, with glacial occupancy increasing northwards.
For example, estimates of the duration of glacial occupancy required for the evolution of characteristic glacial valley forms from previously fluvial landscapes range from 100 kyrs for landscapes beneath large ice sheets (Jamieson et al.) to ~ 400 600 kyrs for glaciated alpine terrains (Brook et al.).
This is because therapeutic efficacy is, in part, correlated with magnitude and duration of receptor occupancy by the drug.
The ultimate goal is to have the phone and car merge into a single unit, where the head unit takes over all the phone functions for the duration of your occupancy in the vehicle.
Taken together, these results suggest that the β2AR signaling is sensitive to the duration of epinephrine occupancy, and certain pathways downstream the receptor is persistent after epinephrine removal.
