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Don't get discouraged by the occasional regression.
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The highest levels indicate occasional regressions of tumors and metastases after vaccination or reflect a stronger clinical impact of vaccine in a randomized trial.
A different situation is found in large B-cell lymphomas: regression of the LH39 meshwork occurs while only occasional regressing vessels are seen.
Numerous studies on xenograft tumour models have demonstrated the marked ability of VEGF-blocking agents to suppress tumour progression, with occasional tumour regression (Kim et al, 1993; Rowe et al, 2000a, 2000b; Huang et al, 2003).
If occasional tumor regressions were also observed in these studies, no DTH responses, peptide dose dependent effects nor T cell responses could be detected [42], [43].
There are occasional spontaneous regressions and good results; but you saw in the figures Dr Martini showed that with amputation we have had a 17% five-year cure rate.
Although MIBG therapy can provide good biochemical and symptomatic responses and occasional impressive tumour regression, it generally has modest therapeutic effects.
Recently published pilot clinical trials of antigenic protein or peptide-pulsed DCs in non-Hodgkin's lymphoma and melanoma have demonstrated the general safety of this approach, as well as some evidence of antigen-specific immune responses and occasional clinical tumor regressions [ 69, 70].
Occasional cases showing spontaneous regression have also been reported.
Although occasional documented cases of regression of untreated tumours occur, untreated breast cancer is generally characterised by very low survival.
Its rate of occurrence progressively increases from the occasional observation of spontaneous regressions to the high rate of complete remissions observed in response to effective treatments.
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