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Since the original drug was never intended for a peripheral target, the intellectual property issues (novelty, non-obviousness) between the non-CNS analogs and the original drug analogs for the CNS target may be minimal.
The midrash makes an analogy between the obviousness that a building has an owner, and that the world is looked after by God.
But today's shortlist still feels fresh and significant, treading a delicate path between obviousness and obscurity.
The Bogdanov brothers have indignantly denied it, but even the Harvard string-theory group was said to be unsure, alternating between laughter at the obviousness of the fraud and hesitant concession that the authors might have been sincere.
The case, which concerns a dispute between rival gas-pedal manufacturers over the definition of obviousness in a patent application, is being billed as the biggest patent issue in years to come before the Supreme Court, which has faced a string of recent high profile intellectual property cases.
Others are breathtaking in their obviousness, like diligent hand-washing.
Forgive the playwright, Mike Bartlett, for the obviousness of the metaphor.
Another work attempts to mitigate the obviousness with subtlety verging on the obscure.
There was an obviousness to this restoration, and I liked that.
Specifically this paper provides a new approach for determining obviousness in this technology area.
You might think that this would be impossible, given the obviousness of the ploy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com