The animal studies further demonstrated that the combination exhibited significant antitumor activity without obvious toxicity.
Besides, no obvious toxicity evidence was obtained during in vivo imaging [7, 14 16].
Moreover, both in vitro and in vivo studies uncover no obvious toxicity for FePt@Fe2O3-PEG nanoparticles.
All high-antimicrobial active compounds showed no obvious toxicity to human fibroblast (HAF) cells at the MIC concentration.
They showed no obvious toxicity without irradiation, but significant generation of singlet oxygen and remarkable photodynamic efficacy after irradiation.
Administration of LXM-10-M produced significant antinociception in hot-plate test, formalin test and acetic acid writhing test in mice, with no obvious toxicity.
In vivo studies revealed that compound 11a displayed potent oral antitumor activity in both hematological tumor cell U937 xenograft model and solid tumor cell HCT116 xenograft model with no obvious toxicity.
The preliminary results showed that at low micromolar concentrations these compounds exhibit obvious toxicity against tumor cells, and the synergistic effect on clinical antitumor agent indicated that at noncytotoxic concentrations, they also evidently enhance the curative effect of vincristine VCR).
PHM/Cit-OVA complexes containing PCL-PEI and PCL-PEG in a 1 1 mass ratio induced strong immune responses in nasal mucosa and serum in vivo without causing obvious toxicity, and Cit-OVA was efficiently internalized by dendritic cells.
The two conjugates were similar in particle size, water solubility and their effects on MCF-7 cell line in vitro, and both of them induced no obvious toxicity in vivo.
In addition, the Pt(IV) derivative of cisplatin, complex 10, exhibited highly selective inhibition in human cancer cells and displayed no obvious toxicity to two human normal cell lines, respectively.
