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On the other hand, obvious nucleotide substitution saturation and base composition bias have been observed in the mitochondrial loci.
No obvious nucleotide and amino acid differences were found for the HBoV3 strains detected in respiratory samples and those in stool samples.
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These questions are especially important given the obvious impact of nucleotide sequence variation on evolutionary conclusions.
It was obvious that single nucleotide polymorphisms (SNPs) were important in genetic variation [ 40].
More detailed analysis showed that similarity at amino acid level was clearly more obvious than at nucleotide level among Bastille-like group phages (Fig. 2).
Thus, it is not obvious whether both nucleotide changes (the first position of each codon) have resulted from the same error during replication or, alternatively, have occurred sequentially towards the rapid fitness escape from unfavorable combinations [ 43].
There is no obvious similarity in nucleotide sequence between the Promoterome inserts of these two genes, but degeneracy and small size of transcription factor binding sites means that the overlap in their expression patterns could still be driven by the same transcriptional control system.
Our visual inspection of each gene found no obvious misalignment of nucleotides, and therefore no data were trimmed from our alignments.
There is, however, no obvious similarity among the nucleotide sequences that flank these non-allelic inteins.
This suggests an obvious mechanism by which nucleotide state may simultaneously control protein-protein association along the filament axis in both the lateral and longitudinal direction.
The first and most obvious difficulty is that nucleotide sequences must have enough variability within and among the studied species to obtain an adequate resolution of the phylogenetic tree.
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