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Morphological observation displayed obvious embryonic development defects in the Dmrt2b morphants.
The protocerebral segment has no obvious embryonic appendage.
We found that mma-1 RNAi) mma-1 RNAiause any obvious embryonic lethality or midoesval arrest inottfs-1(tm4525) mutant animals.
The initial branching morphogenesis of the embryonic mammary gland is hormone independent because mice that are deficient in either estrogen receptor (α or β), the prolactin receptor, the growth hormone receptor, or the progesterone receptor have no obvious embryonic mammary phenotype [ 19, 20].
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However, no comparable anomaly of the bronchial epithelium was obvious during embryonic development, although a few bronchi showed altered cross-sectional profiles (Fig. 2B, left, middle).
Therefore, while it is obvious that these embryonic structures contain the precursors to adult MaSCs, it is not clear whether embryonic cells, themselves, can become long-lived, adult mammary stem/progenitor cells.
The role of the Wnt pathway effector pop-1 (TCF/LEF family) in C. briggsae endomesoderm specification represents yet another case of altered gene function with no obvious change in embryonic cell divisions or tissue morphology (Lin et al. 2009).
In contrast, although the sequence disruption efficiency remained high, individual injection of either tyra-T or tyrb-T did not cause any obvious alteration on embryonic pigmentation, indicating the functional redundancy of tyra and tyrb.
Of the sixteen U3 gene trap proviruses selected in ES cells that we have introduced into the germline, six resulted in obvious phenotypes (typically embryonic death) when bred to homozygosity [ 10, 21, 28- 32].
Another obvious problem is that embryonic cells drawn from some tissue bank may not exactly match a patient's immune system.
Mll3 knockout (KO) mice died around birth with no obvious morphological abnormalities in embryonic development.
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