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The resulting seedlings reached maturity without any obvious developmental abnormality, except for the sterility expected from a 3n rice plant.
The animals--which are more aggressive and impulsive than normal mice, but have no other obvious developmental problems--will also drink twice as much alcohol as normal mice.
Deletion of any single BH3-only gene in mice, on the other hand, does not result in obvious developmental defects (Ren et al., 2010; Villunger et al., 2011), although Bid deletion inhibits Fas-induced apoptosis in certain cell types (Yin et al., 1999).
However, Gpr3−/− mice were viable and exhibited neither obvious developmental defects nor gross neurological alterations.
Silencing or disrupting either AtSOFL1 or AtSOFL2 caused no obvious developmental defects.
B-rafΔ8b/Δ8b and B-rafΔ9b/Δ9b animals were born at a Mendelian ratio without obvious developmental defects.
In spite of the differences in absolute body weights, no obvious developmental abnormalities or differences in general health were observed among the three groups.
Lrig3 mutant mice, on the other hand, exhibit obvious developmental defects that manifest as abnormal morphogenesis of the inner ear and craniofacial structures [27].
Surviving worms at 24 h were about 70% shorter (Fig. 3H) and displayed an obvious developmental delay when compared with control animals.
That Roc2 and Cul5 mutant animals are viable and display no obvious developmental defects is consistent with our analysis of Roc-Cullin interactions indicating that Roc2 and Cul5 bind exclusively to each other.
Knock-out mice of c-cbl, cbl-b and cbl-3 have no obvious developmental phenotypes except in the immune system suggesting that they are functionally redundant [29] [32].
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