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Normal electrophysiological activity was obtained upon differentiation.
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We have studied the temporal distribution and expression of 3R and 4R tau isoforms at different stages of hESCs neuronal differentiation to determine whether neurons with the six tau isoforms and an appropriate tau pattern can be obtained upon maturation.
Interestingly, similar results were obtained upon inhibition of Lck activity.
(Information of primer sequences can be obtained upon request).
The phosphopeptide profiles obtained upon activation of insulin and EGF RTKs gave the largest spectrum of pY events, representing all major signaling pathways (MAPK pathway, PI3Kinase pathway, STAT pathway and PLCγ pathway) under RTK activation responsible for cell growth, proliferation, survival and differentiation.
Primary cells were obtained upon informed consent.
Complementary results were obtained upon request.
Raw data can be obtained upon request.
Primer information can be obtained upon request.
CRP measurements were obtained upon admission.
Details can be obtained upon request.
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