Data obtained up till now have allowed introducing some of these microtubule-targeting drugs into the clinical experimentation phase, whereas others, still in their preclinical phase, represent excellent candidates for a future use in cancer treatment, thus opening new roads towards the development of new, individual, and efficient therapeutic approaches.
Till now, 30 structures were obtained for eukaryotic IMPs from Sf9 expression system and 5 from Hi5 (Table 4).
Till now, GB is usually obtained from extraction of Ginkgo biloba leaves through column chromatography with an extremely low yield and high cost, which can not meet clinical requirement.
Till now, many novel chemicals have been obtained from the monomers of natural compounds by this transformation approach, including flavonoids [ 23], terpenoides [ 24], saponins [ 25] and alkanes [ 26].
Till now, fewer Ca2+ channel toxins have been obtained from scorpion venoms[ 40].
Till now, we get the equally spaced CGH signal.
Till now, more than 300 Lycopodium alkaloids have been obtained [6, 7], which were classified into four structural types by chemist Ayer [8], namely, lycopodine-type, lycodine-type, fawcettimine-type, and miscellaneous-type.
Till now, several test specimens have been used for obtaining the value of fracture toughness (KIc) in asphalt concretes.
Till now, court opinion has been divided on the legality of evidence obtained by tapping wires.
Till now, only hollow carbon spheres with the diameter of few microns were obtained through this method [19].
