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However, a proportion of patients in the current trial obtained prolonged SD, 21.8% at 6 months, which compares with approximately 35 and 10% in the everolimus and placebo arms of the phase III trial at 6 months, respectively (Motzer et al, 2010).
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Floating microspheres have been utilized to obtain prolonged and uniform release of drug in the stomach for development of once-daily formulations.
Combinations of low-methoxy amidated pectin (LMAP) and carboxymethylcellulose (CMC) were used to develop a lyophilized wafer formulation, aimed to obtain prolonged residence and controlled release of econazole nitrate (ECN) in the oral cavity.
These results demonstrate that some patients with MOPP-resistant Hodgkin's disease can obtain prolonged CR following intensive chemoradiotherapy and allogeneic marrow transplantation.
Two independent cohorts of patients in Australia were studied; we report here on the locally advanced cohort, where surgical resection was not possible and the aim of the treatment was to obtain prolonged local control.
The largest increase in ankle passive joint mobility in children with SCP has been obtained through prolonged plantarflexor stretching through ankle casting combined with botulinum neurotoxin type A. However, to our knowledge, there are no published studies on muscle-tendinous adaptations to ankle casting combined with botulinum toxin type A and its effect on ankle joint gait kinetics.
A most likely explanation for these observations is that antifibrinolytic assay is a kinetic-based assay, whereas the equilibrium inhibition constant, Ki, was obtained upon prolonged incubation of the inhibitor with plasmin.
Lapasset et al used a cocktail of six factors (traditional OSKM cassette plus Nanog and Lin28) to effectively reprogram aging cells obtained by prolonged in vitro passaging and showing all signs of replicative senescence, as well as cells derived from people of very advanced (92 101 years) age.
Even larger pores with almost no additional Sg decrease were obtained by prolonging that stage.
Nanocrystals with smaller and more uniform particle size were obtained by prolonging milling time.
If remission is obtained, we prolong immunosuppressive treatment (without corticosteroids) for several months to reduce the probability of recurrence.
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