Exact(2)
The obtained efficacy after 14 days of incubation was 99.3% against Colletotrichum acutatum and 99.8% against Colletotrichum gloeosporioides.
Triplet chemotherapy regimen according to 5-fluorouracil, irinotecan /5-fluorouracil, oxaliplatin, characterized by timed flat-infusion 5-FU administration, without leucovorin, obtained efficacy equivalent to other reported similar combination regimens (5-FU, irinotecan, and oxaliplatin), with increased received 5-FU dose intensity and lower grade 3 to 4 neutropenia.
Similar(58)
Data from clinical trials used to obtain efficacy data demonstrated that LC was associated to less adverse events rates than the comparator (47.4% vs 61.0% with placebo [20], or 77.7% vs 79.8% with calcium acetate [23]).
Such trials will need to be conducted in a high incidence population, to obtain efficacy data within a realistic time frame.
This indicates that early intervention is likely critical to obtain efficacy.
In order to obtain efficacy data for the analysis, our aim was also to conduct a systematic review of RCTs and perform a meta-analysis of the results.
Both, Ahn et al. [ 28] as well as Giuliani et al. [ 27], used an indirect comparison to obtain efficacy data since no head-to-head trials existed.
Our purpose was to obtain efficacy and safety information from a cohort of subjects exposed to latanoprost/timolol fixed combination (FC) for ≥18 months using a prospective, observational design.
The present prospective, noninterventional, observational study was designed to obtain efficacy and tolerability information about a cohort of subjects exposed to the latanoprost/timolol FC for at least 18 months.
An obstacle might be introduced with strict data protections laws, as exporters must either obtain authorization from the patent holder to obtain efficacy and toxicity data or when denied, perform its own clinical studies to collect this data; this can increase the exporter's costs, therefore increasing the drug cost in the importing country[ 28].
It is suggested that results in clinical practice seem to be as good as those obtained in efficacy studies.
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