Exact(5)
We found that about 8.3% of all obtained disease annotations represented less specific concepts.
The boundary metabolite is predicted to be a biomarker of the dysfunctional reaction if the obtained disease exchange interval is significantly different from the healthy exchange interval.
Response evaluation was not available for 13 patients but the overall response rate was 13%, whereas 57% obtained disease control and 43% progressed before or at first response evaluation.
An interesting observation is that patients who obtained disease stabilization after two cycles of treatment had the same PFS and OS with patients that showed disease regression with the RECIST criteria.
The same treatment was associated with disease progression in our patient, while his sister obtained disease stability after 6 cycles, suggesting that further studies are needed to define if the combination of platinum-based drugs and pemetrexed can be used as an option for first-line treatment in PEAC.
Similar(55)
We obtained disease-gene associations from DOLite [ 32].
We obtained disease-disease similarity scores from the literature [ 23].
We obtained disease-tissue associations from the literature [ 28].
Meanwhile, we obtained disease-related pathways of the three diseases from MalaCards database version 1.05 [ 42, 43], resulting in 154 disease-related pathways in total (Additional file 6).
If you cannot obtain disease control, go back to the initial dose.
We obtain disease information from the Online Mendelian Inheritance in Man (OMIM) database.
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