SS supervised subject recruitment and interventions, and obtained subject data.
DZ supervised data management and obtained subject data.
Before any data were obtained, subjects were informed about the risks and benefits of the study and written consent was obtained from each subject.
Results are expressed as five time points: for each subject, data obtained at baseline, 25%, 50 %, 75 % and 100of endurance time were used in the analysis.
Only one isolate, obtained from plasma collected at Baseline, was obtained from an additional PHAEDRA subject (data not shown).
The use of human data in this study did not require an approval from the ethics committee of our organisation (Western Australian Health Department and the Queen Elizabeth II Medical Centre, Perth) as only subject data already obtained for diagnostic testing were used, and all data were de-identified.
In addition, the increase in total HIV-1 DNA production between 96 and 110 h post-infection for isolates obtained from PHAEDRA subjects was not substantive relative to wild type or the isolates obtained from PULSE subjects (data not shown).
The null distribution was obtained by permuting subjects' data between the groups, which makes use of the null hypothesis of no effect of group membership on BOLD signal, and refitting the linear model.
It will also be a valuable expansion of our cross-sectional study if we can recall some of our subjects to obtain longitudinal data on the epigenetic changes as well as on the functional status of metabolic pathways over time in the same individuals.
We did not obtain data on subjects scanned with both CT scanners (inter-individual and not intra-individual design).
In order to obtain data from subjects with long experience of safety promotion work, the ten first designated Safe Communities in Sweden were invited to participate in the study.
