Exact(3)
When the scaling gets even harder, i.e., to the factors of ±20 and +30%, our algorithm can still obtain hit rates of more than 90%, which outperforms other state-of-the-art algorithms like [3,9,10,17,21] (±6%, ±10%, +5% ±15%, −21% ∼ +26%).
These concentrations were chosen to obtain hit rates in the 1 2% range, as estimated via pilot experiments.
Considering the first transcript, hits were counted for each nucleotide, then divided by the length of each bin to obtain hit densities.
Similar(57)
Today, the process of identifying and optimizing peptide mimics is driven mainly by screening to obtain hits, followed by optimization, which might include design based on arranging pharmacophores appropriately in three dimensions.
Hit size was over 400 bp in 50% of all cases, and we did not obtain hits with a length lower than 50 bp due to filtering restrictions.
The bovine human synteny map was constructed through BLASTing 8294 markers from MARC and RH maps (Everts-van der Wind et al. 2004; Itoh et al. 2005) with bovine contigs to obtain hits (defined as E < 10−19) with longer sequences.
Next , 32predictions ranked below the top 1% from VLS were randomly selected and tested experimentally on 1000001 and 1000006 to demonstrate that the obtained hit rate for the top 1% was appreciably better than the background.
The B2G program uses BLAST to find homologous sequences to input sequences and extracts GO terms (Gene Ontology) to each obtained hit using existing annotations.
Annotation of ESTs and extraction of GO terms to each obtained hit using existing annotations was done using the BLAST2GO v1 program [ 31] as previously described [ 27].
These models serve as a basis to establish and validate efficient rationales used to tailor and/or screen virtual libraries with enhanced chances of obtaining hits.
GO terms were derived from the obtained hits and for each sequence they were merged with the already assigned terms.
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