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Retrocopies are assumed not to carry the regulatory regions, but by chance they may obtain functions by recruiting new regulatory elements, and then become functional retrogenes [ 2- 7].
We next subtracted the filtered data from the raw data at each cut-off frequency, and autocorrelated the residuals to obtain functions normalized by their variance.
Combining information from population PK models with PBPK approaches may therefore be necessary to obtain functions to describe the maturational changes in metabolic and/or elimination pathways.
Other advantages of using a Bayesian approach are that it is relatively easy to fit complex models that allow adjustment for covariates when assessing geographical variation in survival and we can also obtain functions of the model parameters such as the relative contributions of the unstructured and structured spatial effects.
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AS is an important mechanism by which genes obtain function diversity.
The local approach consistently outperforms the global approach (Figure 2B) due to the flexibility associated with combining several local substructures to obtain function-specific rules.
To obtain function level behaviors, genes were grouped based on their KEGG metabolic pathway classifications.
RSM is employed in modeling of tensile modulus and strength, and the obtained functions from RSM optimized by GA.
The obtained functions can be optimized through GA, and the optimum variables can be attained as presented in the following sections.
The obtained functions for each pathway were used to evaluate the performance of the proposed FSim method and other existing methods.
First, we show that the obtained function satisfies the initial condition.
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