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AS is an important mechanism by which genes obtain function diversity.
To obtain function level behaviors, genes were grouped based on their KEGG metabolic pathway classifications.
In cases where agreement between methods was lacking or statistical support was marginal, identification of conserved sequence motifs, inspection of predicted structure and clustering of homologous proteins were applied to obtain function predictions.
Although this approach acknowledges functional independence as an important goal of treatment [ 8, 9], the means to obtain function focuses on remediation of the child in the International Classification of Functioning, Disability and Health ICFF) component of body function and structure.
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Retrocopies are assumed not to carry the regulatory regions, but by chance they may obtain functions by recruiting new regulatory elements, and then become functional retrogenes [ 2- 7].
The local approach consistently outperforms the global approach (Figure 2B) due to the flexibility associated with combining several local substructures to obtain function-specific rules.
We next subtracted the filtered data from the raw data at each cut-off frequency, and autocorrelated the residuals to obtain functions normalized by their variance.
Combining information from population PK models with PBPK approaches may therefore be necessary to obtain functions to describe the maturational changes in metabolic and/or elimination pathways.
First, we show that the obtained function satisfies the initial condition.
The behaviour of the obtained function close to the source is investigated.
Proof We now verify that the obtained function u k actually solves the initial value problem (3).
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