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Sinusitis aetiologies were reported to be related to the mechanical obstruction of drainage of the osteomeatal complex region.
Normal pancreatic parenchyma and mild chronic pancreatitis of pancreas downstream to PDA is related to regular and partial obstruction of drainage of this segment into the main duct through the accessory one respectively.
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The sudden obstruction of venous drainage caused by rapid tumor growth or tumor thrombus can result in congestion and further necrosis of tumor tissue and can lead to increased intratumoral pressure [14, 16].
The obstruction of urinary drainage is believed to cause dysplasia and is associated with well-described pathological findings.
Malignant pericardial effusions are present in 10 15% of patients with cancer and are caused by the obstruction of lymphatic drainage, direct extension or hematogenous metastasis [ 18, 19].
This could prevent dilatation of white matter VRS even with obstruction of ISF drainage pathway in the cortical arterioles and leptomeningeal arteries.
In AGS, the paucity of interlobular bile ducts (fewer than 0.4 bile ducts per portal area) [ 24] is believed to underlie cholestasis by causing obstruction of biliary drainage.
One of the major consequences of this failure is the obstruction of lymphatic drainage of fluid and solutes from the brain by CAA that results in the accumulation of insoluble and soluble Aβs in the brain and probably other metabolites that would lead to loss of homeostasis of the neuronal environment.
Primary intestinal lymphangiectasia is a rare congenital disease described by Waldmann in 1961 that is a consequence of obstruction of the lymphatic drainage of the small bowel with secondary lymph vessel dilation.
Abnormal deposits of glycosaminoglycans and elevated levels of fibronectin may thicken the sclera causing obstruction of the suprachoroidal drainage pathway and uveal effusion in these cases [ 6, 7].
The characteristic pathologic finding is dermal lymphatic invasion by carcinoma, which can lead to obstruction of the lymphatic drainage causing the clinical picture of erythema and edema.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com