Exact(3)
To our knowledge, these compounds represent the first reported small molecules that inhibit viral entry via the proposed NHR-trimer obstruction mechanism.
In this work, we employed similarity-based scoring to identify and experimentally characterize 113 compounds, related to 2 small-molecule inhibitors recently reported by Allen et al. (Bioorg. Med. Chem Lett. 2015, 25 2853–59), proposed to act via the NHR trimer obstruction mechanism.
In pre-clinical models of asthma, IL-13 drives the variable airflow obstruction mechanism of AHR [ 5– 7, 9], probably through direct effects on smooth muscle [ 17– 19], but has only modest impact on eosinophilic inflammation [ 5, 9].
Similar(57)
In the mechanical PHV group, the mechanism of obstruction (pannus, thrombosis and PPM) was correctly identified by TTE and TEE in 5/49 (10%) and 17/35 (49%) of cases, respectively.
NPPV theoretically improves the respiratory status of patients with lower respiratory airway obstruction by several mechanisms [37].
Meckel's diverticulum may lead to bowel obstruction by several mechanisms: mesodiverticular bands, volvulus from umbilical attachment, hernia, or intussusception.
Asthma is associated with remodeling of the extracellular matrix (ECM) and increased airway obstruction, and the mechanisms of this process are unknown.
HAART might also potentiate airway obstruction through indirect mechanisms such as aberrant immune restoration.
NPPV theoretically improves the respiratory status of patients with lower respiratory airway obstruction by several mechanisms [ 37].
This finding suggests that IVC compression may be a very early sign during the course of bowel obstruction, when compensatory mechanisms are still effective in limiting IAP increase.
This study was designed to assess the mechanism of obstruction in obstructing colorectal carcinomas.
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