Structural observations indicate that this β-hairpin would obstruct interaction with DNA.
> -wrap-foot> is is now widely accepted that druggable proteins are highly conserved because substitutions in the interface may obstruct target drug interactions (Wang, Wang, et al. 2013).
Alternatively, phosphorylated Tyr18 (pY18) and Ser13 (pS13) in FUNDC1 significantly obstruct their interaction with the hydrophobic pocket and Arg10 of LC3B, respectively.
Direct measurements on biological membranes are obstructed by interactions of chemicals with proteins and other membrane components, complex membrane architecture, and variability of membrane composition.
For instance, obstructing the interaction between HIF-1α and the co-activator CBP/p300 led to attenuation of HIF-induced gene expression and inhibition of tumour growth in a xenograft model [ 42].
Hence, the failure of S. aureus to induce TLR-mediated NF-κB activation in pbMEC is not due to just obstructing the interaction of relevant PAMPs with TLRs (TLR2 in particular) through FCS.
To obstruct peptide opioid receptor interactions, the opioid peptides were labeled with TAMRA at the N terminus.
Interaction can obstruct or promote four clusters of barriers between research and policy: expectations, transfer issues, acceptance, and interpretation.
The T cell receptor (TCR -cluster of differenTCR -clusterD3) signaling cofplex plays an important role in initiation of adifferentiationresponses, but weak interactions have obstructed delineation of the individual TCR-CD3 signalingnteracomplexduring T cell signaling.
After careful analysis, it became apparent that crystallographic contacts obstructed the key interaction driving the observed SAR, namely, formation of a salt bridge between Arg82 and the anionic substituent of this class of inhibitors.
