Sentence examples for obstruct expression from inspiring English sources

We reasoned that some rare codons in the cDNA of the USP18 clone might obstruct expression and therefore switched to an expression construct with codons optimized for expression in E. coli.

Obstructing CCR7 expression at mRNA level in a murine tumor model inhibited lymph node metastasis and lymphangiogenesis [ 196].

Furthermore, inhibition of both NF-κB1 and STAT3 (50 μM) pathways obstructs IL-10 expression to almost undetectable levels.

Also, methylation of DNA resulting in nucleosomal repositioning and high-order chromatin remodeling leads to formation of inactive heterochromatin compartments which further obstructs the gene expression circuit [ 9, 10].

Engagement of the fetal presenting part would stimulate local prostaglandin H synthase 2 expression and obstruct diffusion of high forebag prostaglandin to the rest of the uterus, as reported previously in human pregnancy.

In the evaluation this turned out to be too restrictive as it seemed to obstruct the GP's expression of his recollection of the situation.

These interactions are crucial for post-transcriptional regulation of target gene expression by obstructing the mRNA translation or stability in the cytoplasm, and depend on both the expression levels of miRNAs and target mRNAs [ 2, 3].

In the present paper, we addressed the question whether we can confer inhibitory effects on melanoma cells by obstructing eIF-4A1 gene expression using transient and stable transfection of antisense constructs against eIF-4A1.

However, errors in chromosomal assignments should obstruct the signal of elevated expression divergence on the third and X chromosomes, making our results conservative.

I'm afraid freedom of expression is being obstructed," said one pseudonymous reader.

When only families own the memory, they may unintentionally obstruct societal involvement and inhibit the expression of the horrible event's long-term significance.