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One of the major obstacles in engineering tissue constructs for clinical use is the limit of available human cells.
With the RNA aptamer small molecule strategy, new inputs can be easily implemented in synthetic gene circuits while avoiding some of the obstacles in engineering protein small molecule interactions.
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We postulated that an obstacle in engineering human tissues is the limited replicative capacity of adult somatic cells.
The large degree of ALR redundancy coupled with an incomplete database of ALRs represents a significant obstacle in engineering E. coli for either aldehyde or alkane production.
Thick tissue vascularisation is one of the major obstacles in tissue engineering.
In this context, this chapter will report new advances and obstacles in the engineering of diastereomeric, all-d-enantiomeric and retro-inverso bioactive peptides, with a focus on antimicrobial peptides, mainly highlighting their therapeutic potential.
We propose and analyze an interior penalty method for a finite-dimensional large-scale bounded Nonlinear Complementarity Problem (NCP) arising from the discretization of a differential double obstacle problem in engineering.
Articular cartilage repair remains a major obstacle in tissue engineering.
Semipermeable membranes of cells frequently pose an obstacle in metabolic engineering by limiting uptake of substrates, intermediates, or xenobiotics.
Efficient intracellular delivery of target macromolecules remains a major obstacle in cell engineering and other biomedical applications.
Six female researchers discuss how they overcame social and financial obstacles in science and engineering.
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