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There remain significant obstacles in developing biologics to treat primary biliary cholangitis (PBC).
We also face many implementation obstacles in developing POS, like the incompatibility between Pig data model and Storm data model, the bolts partition problem in topology generation procedure.
TODS abstracts away from service logic most complexities of data management, which have often become major obstacles in developing high quality Internet services.
Given the growing interest in, and relevance of, integrated approaches to STEM education, there is an urgent desire to understand the challenges and obstacles in developing and implementing integrated STEM curricula and instruction.
The optimal design results in this paper are expected to provide a design guideline for multi-axis F/T sensors with significantly reduced cross coupling error, one of the biggest technical obstacles in developing F/T sensors.
Prime obstacles in developing an efficient subdivision-based polynomial constraint solver are the exhaustive, although hierarchical, search of the zero-set in the parameter domain, which is computationally demanding, and their scalability in terms of the number of variables.
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The efficient direct access of therapeutic molecules to the target tissues is still a major obstacle in developing useful therapeutic interventions.
In addition, variable drug sensitivity is a major obstacle in developing therapies for OS.
A major obstacle in developing cyclic peptide therapeutics is that they are generally impermeable to the cell membrane.
The lack of a universal animal model for such scarring has been an obstacle in developing a successful therapeutic strategy.
A major obstacle in developing a Hib vaccine has been limited awareness about the impact of Hib disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com