Results: Challenges, many of them critical, were a regular occurrence: dealing with unforeseen obstacles, establishing and maintaining physician buy-in, establishing and maintaining staff buy-in, implementing the protocol as directed and with minimal intrusiveness, maintaining enthusiasm for the project over time, and knowing where (and where not) to allocate the Study's time, energy, and money.
Mr. Zhou was also confident he could overcome obstacles by establishing direct relations with the government, including the leader at the time, Kim Jong-il, the current leader's father.
But to find out how such a business overcomes obstacles like establishing a customer base, designing an attractive, workable Web site and responding to a flood of new competitors, we will have to wait for someone else's memoir.
The New York market has proved particularly difficult for festival producers, who cite high costs and competition with the city's rich cultural calendar as obstacles to establishing a successful event.
While some gay rights lawyers said that there were still abundant legal obstacles to establishing a right either to gay marriage or to military service by gay soldiers, there was no doubt that the decision had profound legal and political implications.
Similar to many other direct reprogramming methods, our strategy bypassed obstacles in establishing porcine pluripotent stem cells.
Oshima recalls Campisi responding, "It really upsets me when people say, 'I'm a foreigner, therefore I can't do it,' or 'I'm a woman, therefore I can't do it.' " Although immigrants and women might face obstacles in establishing scientific careers that others do not, Campisi told Oshima that those hurdles are no excuse for failing to perform well.
We speculate that the differences in the lava effusion rates and total erupted volume between eruptive episodes in the 1970s and 2000s (Table 3) may relate to 1) a higher rate of intrusion of primitive magma into a mid-depth reservoir in the more recent event or potentially 2) the more explosive initial eruption in 2002 clearing the vent of obstacles and establishing a wider active conduit.
Two obstacles to establishing functional roles for the many candidate sexual development genes that exist remain the time and cost of generating mice lacking the relevant gene, and the absence of any reliable in vitro assay for gene function during mouse gonadogenesis.
Despite the appreciable successes in the study of miRNA properties, there are obstacles to establishing the target genes of miRNAs.
Physicians described how, in consultations through interpreters, they face obstacles in establishing optimal communication [ 15] and found all communication tasks more difficult when an interpreter was used [ 16].
