The lack of graft-host electrical integration is therefore a critical obstacle to development of efficient tissue engineering therapies for heart repair.
The barrier properties of the skin pose a significant but not insurmountable obstacle for development of new effective anti-inflammatory therapies.
Human immunodeficiency virus type 1 (HIV-1) displays very high genetic variability, which is the primary obstacle for development of an effective HIV vaccine and the reason for the emergence of resistance during antiretroviral therapy (ART).
The project will ease a bottleneck that has become a major obstacle to development of the wind-rich Texas Panhandle and other areas suitable for wind generation.
Indeed, given the costs associated with MRI and the dose-limiting effect, ARIAs pose a significant obstacle for development of certain mAbs.
On the other hand, because such antigens are subjected to a great evolutionary pressure, a high level of sequence heterogeneity is expected within natural populations, which may constitute a significant obstacle to development of effective vaccines.
Poor protective efficacy is one of the main obstacles to development of vaccines against schistosomes [ 24, 25].
"There are a lot of obstacles to development in Coney Island," said Charles Denson, whose book, "Coney Island: Lost and Found," chronicles the rise, fall and nascent rebirth of the neighborhood where he grew up.
The obstacles of entrepreneurial development and institutional breakdown create an opportunity to introduce more social entrepreneurship.
Finally, we also present the future trends, prospects, and possible obstacles of the development of advanced MOFs and MOF-derived nanomaterials for more promising and large-scale commercial applications of clean energy.
