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The application of the small device might overcome a major obstacle of applying cytological and molecular analyses of sputum for lung cancer early detection and screening.
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It removes the obstacles of applying AD to adaptive methods and, in contrast to DA, requires for its use only a minimal amount of knowledge about the formulation of adjoint PDEs and their boundary conditions.
Obstacles of applying GWAS to sickle cell anemia and other hemoglobinopathies include: the limited sample sizes, the issue of LD, interpreting associations with SNPs when a biological connection is unclear, and dealing with gene-gene and gene-environment interactions [ 21].
The author ignores other important issues, and a more balanced recognition of obstacles to applying a genome scan to clinical care would strengthen the article.
There is no apparent obstacle to applying (ii) to wider classes of languages than the class considered for special purposes of their investigation by Tarski and Givant.
The main obstacle in the way of applying CBP with S. cerevisiae is considered to be the sufficiency of CBH production, estimated to require approximately 20- to 120-fold improvement [ 19].
The lack of such a graph representation was a key obstacle for applying combinatorial methods.
One of the obstacles to applying neural networks in industry is a lack of confidence in model predictions.
Finally, to revisit a statement made in one of our first papers describing this method [28], one of the obstacles to applying the MOLS technique to ab initio protein structure prediction was the non-availability of an appropriate potential function with a deep and fairly wide minimum in conformational space corresponding to the native structure.
One of the obstacles to applying this technology to non-model organisms is sufficient sequence data from which array features can be designed.
Limitation in sample quality and quantity is one of the big obstacles for applying metatranscriptomic technologies to explore gene expression and functionality of microbial communities in natural environments.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com