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The main obstacle in application of model checking in practice is the state space explosion problem [ 20].
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This is a serious obstacle in applications such as law enforcement and surveillance systems.
A category of gas sensing hollow core waveguide that was operated in near infrared was designed to solve their major obstacles in application including high scattering and high losses.
However, peeling of the coating during stent expansion is the main obstacle in stent application.
Cisplatin-induced testicular damage is a major obstacle in the application of cisplatin as chemotherapeutic agent.
The aggregation of graphene nanosheets is an obstacle in the application of the reduced GO in solution, hindering the electrochemical performances [15,16].
A major obstacle in the application and acceptance of population models is the communication of the methodology and the complexity of the models.
Limited tissue penetration ability of UV radiation presents a serious obstacle in the application of UV-sensitizing NPs of TiO2 and ZnO in cancer therapy.
However, high cost of reactor which can tolerate high pressure conditions is a big obstacle in its application on large scale (Agbor et al. 2011).
This issue has been acknowledged as a major obstacle in the application and advancement of high-resolution imaging technology and is the current resolution-limiting factor in nuclear medicine thorax imaging [8, 9].
The obstacle in the application of naturally occurring AMPs is their high toxicity, promoting hemolysis, nephrotoxicity and neurotoxicity [ 7].
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