Sentence examples for observing replication from inspiring English sources

We identified cellular protein kinases involved in HCV replication by observing replication and clustering of the infected cells upon silencing of protein kinases (2157 siRNAs targeted 719 human protein kinase genes).

Frum et al. (2008) observed replication pausing near newly replicated origins in early S phase in human fibroblasts.

We observed replication fork stalling at all types of dinucleotide microsatellites, detected as bulges on replication arcs that were not present for the control plasmid.

The failure to observe replication intermediates in the TG-less DSBs was not caused by loss of DNA to unchecked resection (Supplementary Fig S3).

To substantiate the speculations presented herein, it will be necessary to observe replication intermediates via electron microscopy or 2D-gel analysis.

We observed replication of two markers within ZNF385D and performance on the Picture Vocabulary Test (P = 0.00245 and 0.004173) (Table 5).

We observed replication fork stalling at all dinucleotide microsatellite sequences in a length-dependent manner, suggesting that replication fork restart/template switching mechanisms may also be operative within these regions of the human genome.

Among non-East Asian populations, we observed replication of the association in participants of European descent from the DIAGRAM Consortium (p = 8.6 × 10−3), with OR 1.06 and (95% CI 1.02, 1.12) (Table  3 and Figs  3 and 4).

Combined, the observation of fewer DSBs, reduced predilection of DSBs for origins of replication, lack of observed replication fork instability, and S-phase arrest that is adequately rescued with supplemental thymidine in UNG+/+ cells suggests pemetrexed-induced toxicity is more related to dTTP depletion than to dUTP misincorporation.

The discrepancies between the observed replication characteristics in these studies with our study could possibly be explained by the fact that in our study the replication characteristics of passaged Sabin type 1 were studied, meaning that the virus has had 5 passages to adapt to the new cell line.

Since Raschle et al. [18] also used concentrated nucleoplasmic extracts but did not observe replication-independent repair, we favor the latter interpretation.