We tabulated the shared pathways for all disease pairs (Table S7) and quantified the significance of observed pathway overlaps by performing a hypergeometric test for each database separately (Figure 4A).
Having observed pathway differences, we aimed to identify the largest gene expression differences between MCF7 and MCF7-LTED cells exposed to YC-1.
Our proposed model is a probabilistic combination of a Markov mixture model which identifies frequently observed pathway clusters and an ensemble of supervised techniques each trained locally within each pathway cluster to classify the response.
This observed pathway redundancy' underlines the necessity of comprehensive genetic approaches to make informed decisions on how to employ future targeted molecular therapies most effectively for the benefit of individual MM patients.
As a consequence, we observed pathways that were significantly enriched with such driver genes.
The identified components correspond to a cluster of frequently observed pathways that have a similar structure.
After extracting all observed pathways we label each path with the response label of the original microarray experiment.
Among mRNAs differentially expressed, a significant enrichment of genes involved in cellular import and export, response to toxins, and oxidative stress was observed, pathways that are connected to drug response at least on a global tumor level [ 32].
Transcripts related to artemisinin biosynthetic pathway were also observed in pathway annotations; artemisinin, the end-product of the pathway is a proven anti-malarial agent [ 43].
Upon analyzing the top 20 KEGG pathways, dominance was observed for pathways belonging to ribosome (8.43%) followed by plant pathogen interaction (5.75%) and plant hormone signal transduction (4.56%).
Flies and urine observed along pathway".
