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A clinical trial's power depends on the probability of observing an effect of the tested drug in the trial population, on the size of this effect, and on the heterogeneousness of the judgment criterion in the population.
The procedure should maximise the chances of observing an effect, without introducing a bias under the null.
We therefore tested a larger dose to ensure the best possibility of observing an effect and because there is not evidence of an increased risk of side effects with the higher dose.
Although observing an effect on one of many endpoints due to chance is likely, observing concurrent positive trends across several outcomes by chance is usually unlikely.
This finding is in the opposite direction to what would be expected if we were observing an effect of therapy on cartilage damage.
It was necessary for us to achieve a balance between resources, compliance with the protocol and observing an effect of the supplement on micronutrient status.
Similar(48)
We observed an effect of pesticides on seedling diversity only at sites 90 100 m from edges (Fig. 3).
Statisticians will tell you it is possible to observe an effect and have reason to think it's real even if it's not statistically significant.
To observe an effect due to potential non-commutativity we only need study how visibilities change in response to different phases in the interferometer.
These short- and long-term effects were absent in the sham group where small reductions were observed, an effect more consistent with previous placebo PET studies.
But soon he stopped taking it off after workouts, and even took to wearing a Phiten T-shirt under his hospital scrubs and has observed an effect at work, too.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com