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The paradox is that, for the latter type of pinning site, one still observes alignment of Ld domains along the actin fibers, albeit weak.
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Optimal catheter access to all pre-defined control points and the quality of CT segmentation and 3D CT reconstruction may constitute further reasons for observed alignment inaccuracies in the mentioned areas.
A simulation model that incorporates these ingredients is able to reproduce the experimentally observed alignment of Ld domains, even when the pinning sites themselves energetically favor the Lo phase.
We realigned all reads within candidate SV sites using Smith Waterman-based alignment utilities provided through the Biostrings package (Pages et al., 2013) in Bioconductor (Gentleman et al., 2004), with parameters reflecting the probabilities of observing alignment errors, explained further in Section 2.4 and Supplementary Material 'Smith Waterman alignment parameters' (Malde, 2008).
Analyzing the course of the Risk Model project and as indicated in the findings, we observed alignment efforts made by both RIVM and the Inspectorate; investigators, inspectors, and managers tried to create alignment within the bounds of their reach, both according to the institutional procedures at stated moments and according to the circumstances in the project.
However, the number of substitutions was different between the expected and observed alignments; therefore, the read was classified as incorrectly mapped.
As an alternative option, we further extended the DP alignment to observe constrained alignment space by only considering gap open and gap extension events that can be accommodated by the reference MSA.
Due to the similarity in the alignment structure, it was observed that alignment of the functionalized CNFs was independent of the functional groups attached to the CNFs.
It was observed that alignment was dependent on the channel width, and narrow microchannels (20 μm and 30 μm) promote alignment of smooth muscle cells.
Refinement of the X-ray fiber diffraction pattern of polyester 6-12 allows to determine the c-chain axis shift between the molecular chains, being observed an alignment of the CH2 O methylene groups with the CH2 O oxygen atoms of neighbouring chains.
In the experiment, we observed different alignment morphology with different width of nano-stripes.
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