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The number of women observed with advanced cancerous lesions has drastically reduced since introduction of the opt-out screening.
An increased risk of death was also observed with advanced stage as compared to stage I with HR = 4.43 [2.63-7.46], HR = 8.80 [5.81-13.34] and HR = 13.07 [8.26-20.66] for FIGO II, III and IV, respectively.
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PSR 0628-28 is an X-ray emitting radio pulsar which was observed with the advanced CCD imaging spectrometer (ACIS) on board Chandra on 2001 November 4 and on 2002 March 25 for 2000 and 17,000 s, respectively.
In fact, the response rate for temsirolimus in NEC compares favourably to that observed with sorafenib in advanced renal cell cancer, where the RECIST response rate is less than 5% (Ratain et al, 2006).
Because patients on ipilimumab may have delayed responses or durable stable disease even after apparent disease progression, these new immune-related response criteria are now evaluated to capture additional response patterns observed with immune therapy in advanced melanoma beyond those described by conventional assessments.
Pharmacokinetic analyses in the current study indicated that lenvatinib exposure with coadministration of carboplatin and paclitaxel was similar to that observed with lenvatinib monotherapy in patients with advanced solid tumours (Yamada et al, 2011; Boss et al, 2012).
In locally advanced disease, the longest survival was observed with radiotherapy plus chemotherapy (Table 6).
Additionally, it was observed that those with advanced disease defined as advanced disease greater than 6 months before study entry seemed to do better with the ganetespib and docetaxel combination therapy with regards to progression free survival (n = 177, adjusted HR of 0.74, p = 0.0417) and overall survival (adjusted HR = 0.69, p = 0.0191) [49].
Pulmonary hypertension (PH) is commonly observed in patients with advanced idiopathic pulmonary fibrosis (IPF).
Erlotinib was the only agent approved based on demonstrating improved survival, which was observed in patients with advanced NSCLC who previously had been treated with chemotherapy.
Because this model achieves bacillary burdens that are comparable to those observed in humans with advanced pulmonary TB, it mirrors levels of mycobacterial urease in patients with TB.
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