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The antiviral activity observed was specific, dose-responsive and potent, suggesting that further exploration of PPMO HP1 as a potential HEV-specific antiviral agent is warranted.
Slides were incubated with normal serum alone as a negative control to ensure that any staining observed was specific.
To confirm that the effect observed was specific for NET4/TMEM53 knockdown the experiment was repeated using oligos si1, si2, and the esiRNA.
To find out whether the defect observed was specific for macrophages we tested other immune cells for their response to mitogenic stimuli by 3H-thymidine uptake assays.
To determine if the effect we observed was specific to Wg target genes, we examined the expression of the Mad target gene spalt major (salm) [40].
To ensure that any interaction we observed was specific, we also prepared a LOC domain fused to SV40 large T antigen (LOC-SV40TAg) and a CAT domain fused to p53 (p53-CAT).
Similar(42)
Although overlap was observed between the different ETS classes, most of the peaks observed were specific for a given factor, underscoring the specificity of the ETS-family members.
With these dramatic effects observed for 68Ga-DOTATOC, a logic question was to verify whether the effect observed is specific for the 68Ga-radiocation, or whether it applies to other trivalent metals used in nuclear medicine as well.
Several control experiments were performed to ascertain whether the effects observed were specific to Pak1 knockdown.
We cannot conclude from the evidence presented here that the Tregs observed are specific for TBHsp70.
It will be very important to determine whether the response that we observed is specific to "immature neurons" or whether it represents a more general mechanism.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com