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In 24 patients (18.8%) we observed the combination of positive LUS and positive PCT (>0.5 ng/ml).
In 38 cases (29.7%) we observed the combination of negative LUS and negative PCT (<0.25 ng/ml).
For the same samples in negative mode, we observed the combination of repeated intense peaks with masses about 162 m/z, referring to fragment [Kyn − H2O − CO]−, and about 290 m/z (possible belong to dimer of fragment with mass 146 Da (see above)).
They observed the combination of ROCK1 with Erk1/2 in neuron cells as well.
Interestingly, in both cell lines tested, we observed the combination treatment to be synergistic, as mentioned in Fig. 7c.
Although no objective responses were observed, the combination showed evidence of immunologic activity and 3 patients showed stable disease for ≥ 4 cycles.
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Enhancement of cisplatin-mediated apoptosis was observed in the presence of H-1PV, suggesting apoptosis may contribute to the reduced viability observed with the combination.
The smallest number is observed in the combination of Oceania and the Americas.
The decrease observed in the combination of Nutlin-3a with Doxorubicin or Cisplatin, indicates that Nutlin-3a potentiates Doxorubicin and Cisplatin, whereas the increase in IC50 observed for the combination with Methotrexate indicates that Nutlin-3a inhibits Methotrexate.
This decrease was observed whenever the combination was implemented.
No increased toxicity was observed with the combination.
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