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The computational results offer a rationale for the experimentally observed susceptibility of the Cys49 thiolate toward small-molecule electrophilic agents, and support the recently proposed stepwise protonation mechanism of the C-terminal Zn-coordination complex.
The herein observed susceptibility of Gram-positive bacteria toward Rhododendron leaf extracts contrasted the results obtained with the majority of Gram-negative tester bacteria.
We further assume that three hospital-related effects are involved in G(t i, z i ): 1) an effect associated with being at hospital, 2) an effect associated with the observed susceptibility of the patient to infection when he/she is at hospital, and 3) an effect associated with his/her observed exposure to infectious persons met at hospital.
Taken together, our observations indicate that the absence of VDR is accountable for the observed susceptibility towards biliary-type liver injury.
Secondly, this study provides mechanistic data supporting a role for MHC isoform switching and altered calcium handling as a basis for the observed susceptibility to pump dysfunction in LCR rats.
Taken together, these results therefore suggest that the observed susceptibility of egr1 and egr3 mutants to Gram-positive cocci is rather due to the genetic background of the Regg1 line but not associated with egr loss of function.
Similar(43)
Although rifampin-resistant meningococcal disease is still rare after 30 years of using rifampin for chemoprophylaxis and ciprofloxacin resistance has rarely been observed, susceptibilities to chemoprophylactic agents should be monitored to ensure that recommendations are sufficiently effective to minimize the occurrence of secondary cases.
A considerable overlap has also been observed between susceptibility loci for CD and susceptibility for infectious diseases [ 27].
Regarding the other PDF-Is, we did not observed a susceptibility level similar to that obtained with actinonin.
We observed that susceptibility to CrPV varies in different genetic backgrounds commonly used in Drosophila research (Figure 1B, p<0.0001) and that females are slightly more sensitive to CrPV infection than males (Figure 1E, p = 0.0002).
Similar results were observed in susceptibility to pneumococcal CAP.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com