We observed no suggestion of such a U-shaped pattern (data not shown).
We also observed a suggestion of reduced risk among current users of OCs that was independent of duration of use.
We also observed a suggestion that the association between Δ r−l and breast cancer risk might be strongest for poorly or undifferentiated tumours.
We observed some suggestion that preconception maternal and paternal urinary concentration of BPA and specific phthalate metabolites may be associated with smaller birth size and increased gestational age, though the findings appeared to be parent and chemical specific.
We found no association of diabetes with intakes of total fish, lean fish, or shellfish in adjusted models, but we observed a suggestion of a modest inverse association for fatty fish intake.
This may be an indication that this item is more distinctive, and less strongly consistent with the content of the remainder: when H i values in this range are observed, one suggestion for a practical step in the analysis is that we could remove this item, and recompute H i values for the remaining set of items.
For lung cancer, we observed a suggestion of a raised risk of lung cancer in the 12 months after start of treatment with an angiotensin receptor blocker (hazard ratio 1.11, 0.99 to 1.27), followed by a protective association with longer duration of treatment.
Living within 2 miles of a high-priority site was associated with slightly but not statistically significantly increased risks of fetal death (OR = 1.11; 95% CI, 0.97 1.27 for those living > 1 mile to 2 miles; OR = 1.09; 95% CI, 0.95 1.25 for those living within 1 mile), and we observed no suggestion of a trend with decreasing distance (Table 3).
As indicated by Begovich and colleagues, the chromosome 1 linkage suggestion observed in the ASP analysis of the North American Rheumatoid Arthritis Consortium genome scan is not explained by the findings of the PTPN22 association [ 12].
In the same way, the chromosome 2 linkage suggestion observed in the genome scan of our laboratory could not be totally explained by the findings of the ITGAV linkage; hence, with the overtransmission observed in the TDT, the allele sharing expected for the affected sib-pair siblings would be about 53% and would necessitate thousands of sibling pairs to be revealed.
