Sentence examples for observed substantially reduced from inspiring English sources

For the JRCSF-N301A mutant, we observed substantially reduced neutralizing activity relative to wild-type virus with all serum samples, indicating that neutralizing activity was at least somewhat dependent on glycosylation at Asn301 (Fig. 6d, left).

We observed substantially reduced angiogenesis in apoptosis-suppressed xenografts as demonstrated by CD31+ endothelial cell density.

We observed substantially reduced plaque formation in ApoE −/− Dgat1 −/− mice compared with ApoE −/− mice.

In further support for an organelle-anchoring role of NFs, we observed substantially reduced numbers of ER vesicles in axons of NF-L null mice despite the absence of detectable effects on fast axonal transport rates or on synthesis and export of these fast transport cargoes into axons.

In contrast, we observed a substantially reduced lifespan in mice reconstituted with either Bax −/− Bak −/− (median survival: 190 days, range: 105 357 days, n=20, P<0.0001 versus WT) or Bok −/− Bax −/− Bak −/− (median survival: 195 days, range: 111 402 days, n=22, P<0.0001 versus WT) FLCs.

Finally, when discontinuation does occur, there may be value to gradually discontinuing lithium when appropriate, given that gradual discontinuation has been observed to substantially reduce the risk of mood episode relapse [ 56, 57].

In agreement, we observed that TRF2 substantially reduced the mobility of telomeric DNA even in 0.3% agarose gels with the majority of the complexes not entering the gels (Figure 1A).

Our results validate the primary culture of SCCD in terms of the presence of all the genes that participate in Ca2+ absorption and regulation, although the relative expression level of TRPV5 and TRPV6 was observed to be substantially reduced in culture compared to the native cells.

The observed membrane binding was substantially reduced by preincubation with MRS 1220 (100 nM, 30 min at 22°C; Fig. 1), indicating that most of the membrane-localized ligand could be attributed to specific binding to A3AR-GFP.

Levy et al. observed that newborn plasma conferred substantially reduced BLP-, LPS-, and imiquimod-induced TNF-α release by adult monocytes [28].

Keene et al.[ 132] transplanted prostaglandin receptor (PTGER2 -deficient (EPTGER2 -deficientrow into irradiatEP2APP AD mice, and observed that lesion sizes were substantially reduced in mice receiving knockout bone marrow compared to mice receiving EP2+/+ marrow.