In both HNX14C and HNX22B cell lines, synergistic growth inhibition was observed on schedule 2, whereas schedules 1 and 3 demonstrated antagonistic effects.
This phase II trial was not designed to compare the antitumour activity observed on Schedule 4/2 and the CDD schedule.
A higher ORR was observed on Schedule 4/2 (11.1%) vs CDD (2.1%), and a higher median OS was observed on the CDD schedule (37.1 vs 23.4 weeks, respectively).
When perforation or post-ESD bleeding was observed, the schedule of discharge and meal resumption was changed depending on the individual patients' condition.
There were no DLTs of thrombocytopenia (grade 4) observed in schedule B. On the basis of these results, volasertib was considered tolerable in Asian patients with solid cancer at the determined doses.
Depending on the number of objective responses observed on Schedule 4/2, sample size for the CDD cohort was determined using either a two-stage design (if ⩽5 confirmed objective responses were observed) or a single-stage design (if ⩾6 confirmed objective responses were observed).
However, despite the low overall response rate, we were encouraged by the time-to-event results obtained, which we feel are concordant with a signal of activity and with time-to-event data observed on Schedule 4/2 (4 weeks on treatment followed by 2 weeks off; Socinski et al, 2008).
DeDeCC requires the contributors to submit their theoretical delays for a single baseline, i.e. Westford-Wettzell, using a given observing schedule and Earth rotation parameters.
SWAS was designed to measure water, oxygen, and carbon in gas clouds around the galaxy, but a gap in the observing schedule seemed best filled by a star called CW Leonis, one that should have had practically no detectable water anywhere near it.
We did not keep track of the random sequences of plants generated for each experimental population on each pollination day so we used observed flowering schedules to calculate the expected proportion of pollen received from transgenic plants (PPR) for each weedy plant.
