Sentence examples for observed requirement from inspiring English sources

The observed requirement for NMDA receptor activation to trigger ER fission raises the possibility that specific signaling pathways initiated at the NMDA receptor, rather than a general requirement for high cytosolic calcium, are important.

The observed requirement of a higher concentration of the Rock inhibitor needed in hES cells may be due to species differences or the different culture environments in which ES cells grow.

The observed requirement for specific molecules, including ZAP-70, LAT, SLP-76, and Vav1, in T cell development reflects conditions in which this diverse set of alternative pathways is severely limited by the effects of regulators, notably including Cbl.

Given the observed requirement for decrease in both pERK and pAKT downstream of mutant NRAS and the intense efforts to develop inhibitors targeting BRAF, MEK1/2 and PI3K in progress, we sought to understand if combined knock-down of RAF or MEK with PI3K would be an effective strategy for treatment of NRAS mutant melanomas.

These data suggest that the observed requirement for Cx43 in mural cell-mediated endothelial inhibition is a general phenomenon.

Surprisingly, JAK/STAT signaling is known to suppress hematopoiesis in Drosophila [ 29], in apparent contradiction to the observed requirement for this pathway in the cellular immune response.

As others have observed, that requirement would be like requiring the justice system to eliminate crime by a certain date.

We observed no requirement of a blood transfusion and no morbidity in both hepatic resections.

As we observed a requirement for RBP-J in maintaining high levels of M2-asscoiated genes in vivo in chitin-elicited PECs (Fig. 2A), we wished to further characterize RBP-J-mediated regulation of M2 genes.

Although the beneficial effects of chaperones in preventing the aggregation and improving the trafficking of PMP22 have been repeatedly observed, the requirement for HSP70 in events remains elusive.

The observed transfusion requirement paralleled the predicted transfusion rate as reflected by the Trauma-associated Severe Hemorrhage score from 3.3 (± 3.0) to 15.4 (± 4.9).