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The observed ratio values for the first four protocols are median of medians of ratios (MMR) from four replicate hybridizations.
The most commonly observed ratio is 3 1, but 2 1, 5 1, 5 2, and 1 1 have also been described (Boggs 2001).
A tumor was considered amplified if at least twice as much gene signals as compared to the corresponding centromere signals were observed (ratio gene: centromere ≥2.0).
The main result of our current methodological work was the introduction of a new, simplified approach to compute predicted values and derive "predicted:observed" ratio of outcomes and assess calibration in validation studies of CPRs.
We employ a pragmatic approach to introduce new, simplified methodology of computing the predicted number and "predicted:observed" ratio of outcomes in validation studies of CPRs for assessing calibration in systematic reviews.
In the highest 10th of risk, the predicted:observed ratio was 1.01 for men and 1.02 for women, suggesting good calibration in this group.
This compression is also observed when the observed ratio is binned according to the magnitude of the fold change.
The observed ratio fitted well with the expected ratio with respect to RM6844 marker with a p-value of 0.4392 (Table 3).
The observed ratio of proton to helium intensities does not change significantly over this energy range.
The observed ratio did not fit the expected ratio 1 1 (χ2 = 11.57, P = 0.00067), probably because of the reproductive barrier, as described above.
This can be compared with the observed ratio in the Local Interstellar Cloud reported by Kimura et al. (2003): δ = 0.5 ± 0.1.
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