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These results implicate that RIPC does not exert direct anti-inflammatory effects and that the previously observed protective effects are mediated through other mechanisms.
The observed protective effect of a history of self-harm (including attempted suicide) is novel, unexpected and at odds with our other findings; further investigation is required.
The scientists consistently observed protective effects on HDL from moderate intake of all types of alcoholic beverages.
Similarly, we observed protective effects of ALT diet on the renal microvasculature.
The observed protective effect of the water treatment tablets is self reported, thus may lead to bias.
Some authors have observed protective effect against CIN [ 215– 219]; others have denied any beneficial results [ 220, 221].
Interestingly, they observed protective antitumor responses when targeting pDCs with simultaneous administration of a TLR agonist [ 73].
Some authors have observed protective effects against CIN [ 211, 212]; others have denied any beneficial results [ 135, 213, 214].
Brown et al. observed protective effects of TNF and IL-1β in a model of ischaemia/reperfusion injury.
This M2 macrophage accumulation may contribute to the previously observed protective metabolic activity of adipose tissue during critical illness.
The observed protective effect of statins seemed to be much diminished or absent when we compared patients who stopped their statin with those who never started.
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