Sentence examples for observed profound effects from inspiring English sources

We observed profound effects of ethanol on the MOP receptor surface density and mobility, as well as on the dynamics/organization of lipid constituents in the plasma membrane.

By using optical mapping and submaximal levels of hadp1 knockdown, we observed profound effects on Ca2+ handling and on action potential duration in the absence of morphological defects, suggesting that Hadp1 plays a major role in the regulation of intracellular Ca2+ handling in the heart.

We observed profound effects of tobacco smoke exposure in BBs and BAL cells of volunteers and found CYP1A1, CYP1B1, and GSTP1 to be up-regulated in BBs and alveolar macrophages of smokers, whereas others transcripts were differentially expressed and, in some cases, even oppositely regulated (i.e., CYP3A5, EPHX1).

All analyses were carried out separately for males and females because we initially observed profound sex differences in the effects of prenatal BETA treatment (F0 pregnancy) on body conformation and behavior in young F2 offspring.

Unlike previous reports, we observed profound differences in user profiles.

In contrast, when these cells were placed into three-dimensional organotypic culture conditions, we observed more profound effects.

Importantly, we have observed other profound effects in whole co-culture without mast cell stimulation [ 28] and therefore feel confident that we have not overlooked important mast cell mediated effects on ASM survival or proliferation.

These results suggest that the microbial communities reflect the influences of highly localised biogeographic factors and vineyard management, with the most profound effects observed after deep tillage.

Nevertheless, changes in the Ig-VH genes were detected, with the most profound effects observed 7 months after the beginning of therapy, during the early regeneration phase.

Thus, in two arthritis models, which are independent of adaptive immunity, intact effector mechanisms in myeloid pten -/- mice have been observed, highlighting the profound effect of PTEN in APC for the induction phase of immune-mediated arthritis.

In our experiments, the absence of an effect of depleting VPS20/CHMP6 on cell surface MHC class I was observed despite a profound effect on the morphology of the endosomal system with the appearance of enlarged, ubiquitinated compartments in up to 80% of the cells.