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Recently, we have observed predisposition of patients with low MBL-producing genotype (LXA/LYB, LYB/LYB and LXB/LXB) to develop SLE and autoimmune hemolytic anemia (AIHA) [ 24].
It is thus possible that overexpression of this gene is a consequence of interaction among factors that underlie the observed predisposition of Golden Retrievers to hemangiosarcoma.
Thus, our findings cannot explain the observed predisposition of women regarding this phenomenon.
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Finally, for some inversions an additional direct consequence has been observed: the predisposition to other rearrangements, mainly copy number alterations and translocations [ 22].
18 We did not observe any predisposition for other lesions such as cysts, desmoids or mammary tumours.
Additionally, we observed an increased predisposition for TTH among participants with an education level of five or more years compared with healthy participants.
The breed predisposition observed in the current study indicates a genetic susceptibility to gastric carcinoma.
Tumours with indistinguishable pathology were observed in the predisposition controls but at a much lower frequency (6%), with survival analysis providing clear evidence that SB mutagenesis enhanced the predisposition of Ptch+/- mice to MB (p<0.0001, Figure 1d).
These data further support the hypothesis that p53 can induce apoptosis through the modulation of specific DExH-containing DNA helicases, and may have implications for the cancer predisposition observed in these genomic instability diseases.
Allergic predisposition was observed in 13.7% of the participants.
In this study, DF proteins and the SP proteins are observed to have higher predisposition to be a part of protein complexes than the SF and the DP proteins respectively.
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